Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
Abstract Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase.PKM2 expression is associated with embryogenesis, tissue regeneration, Outdoor End Table and cancer.PKM2 is also the pyruvate kinase isoform expressed in most wild-type adult tissues, with PKM1 restricted pr